Symposium CRPP Synapse & Trauma

Aversive memories: Translating Basic Science to Clinical Treatment



In today's turbulent world, stress and trauma have emerged as major risk factors for various psychiatric disorders. Across the entire spectrum of trauma-related disorders, cognitive-behavioural psychotherapy, which seeks to modify aversive memories, is currently the recommended first-line treatment. Yet, in clinical practice the majority of patients remain symptomatic. This has led to high-profile calls for developing adjunct pharmacological therapies. During the same time, advances in synaptic biology yielded a wide range of compounds that modify synapses themselves, the surrounding extracellular matrix that shapes their properties, and the daily rhythms of sleep and wake that govern their strength. Our Clinical Research Priority Program «Synapse and Trauma» connects these disparate strands and delivered novel insights for approaches to alter aversive memories. We focus on the combination of psychotherapy with pharmacological agents that modulate intra-synaptic signaling. Along with esteemed national and international colleagues from basic and clinical science we will in our symposium discuss such novel approaches to tackle aversive learning and memories. We will also engage in discussing the unique challenge of translating basic science findings to practice and to bringing them to clinical application.



Coffee, snacks and lunch, as well as an apero will be provided for registered participants.

SGPP Credits

Symposium participation will be recognized with 5 SGPP credit points.

COVID-19 safety and hygiene information

Due to COVID-19- related restrictions, places are limited to 80 persons and a COVID-19 certificate incl. ID Card will be required from participants upon entering the lecture hall. Registration is open from 8.15am on the day of the symposium.


Participation in the symposium is free, but registration is required (Deadline 15. 10. 2021). Please register via the website:



Invited Speakers Prof. Dr. Emily Holmes Karolinska Institute Stockholm & Department of Psychology, Uppsala University (SWE) Prof. Dr. Dominique De Quervain Department of Cognitive Neuroscience, University of Basel (CH) Prof. Dr. Merel Kindt Department of Psychology, University of Amsterdam (NL) Prof. Dr. Raffael Kalisch German Resilience Center & Johannes Gutenberg University Mainz (GER) Prof. Kim Q. Do Centre for Psychiatric Neurosciences, University Hospital of Lausanne (CH) Dr. Bianca A. Silva National Research Council of Italy, Institute of Neuroscience (ITALY) Prof. Dr. Tomas Ryan School of Biochemistry & Immunology Trinity Biomedical Sciences Institutes Trinity College Institute of Neuroscience Trinity College Dublin (IRL) UZH Hosts and Sessions Chairs Prof. Dr. Dominik Bach Max Planck UCL Centre for Computational Psychiatry and Ageing Research Prof. Dr. Steven Brown Institute of Pharmacology and Toxicology, Chronobiology and Sleep Unit Prof. Dr. Birgit Kleim Department of Psychiatry Psychotherapy and Psychosomatics Prof. Dr. Erich Seifritz Department of Psychiatry Psychotherapy and Psychosomatics Prof. Dr. Shiva Tyagarajan Institute of Pharmacology and Toxicology, Neurodevelopmental Pharmacology


University of Zurich, Hörsaal KOL-G-217, Rämistrasse 71, 8006 Zurich



Datum der Veranstaltung

29. Oktober 2021

Dauer der Veranstaltung

09.00 - 18.00 h


15. Oktober 2021

Symposium Synapse & Trauma

Stand: 16. September 2021

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